How to remove and reinstall the rear differential in a Lexus RX350?

Raise the rear of the vehicle, support it on jackstands, block the front wheels, and place the transmission in Neutral with the parking brake off. Drain the differential lubricant. Remove the drive axles from the differential. Mark the relationship of the driveshaft to the pinion flange, then unbolt the driveshaft from the flange and suspend it with wire to avoid stressing the center support bearing. On models with an electromagnetic control coupling, disconnect the electrical connector and secure the harness out of the way. Remove the rear exhaust pipe assembly. On Highlander and 2004 and later RX 330/350 models, remove the rear subframe and differential assembly. Support the differential with a floor jack, remove its mounting bracket and bolts, then lower and remove the differential. Installation is the opposite of removal, ensuring all fasteners are tightened to the appropriate torque values and filling the differential with the correct lubricant.

Genuine Lexus RX350 Differential

Front Differential

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25 Differentials found

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Lexus RX350 Carrier Assembly, Differential
Part Number: 41110-48104
$1090.19 MSRP: $1511.14
You Save: $420.95 (28%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Carrier Assy, Differential, Rear; Carrier, Differential Assembly
- Manufacturer Note: *FGR=41:18=2.277
- Position: Rear
- Replaces: 41110-48103, 41110-48102, 41110-48101
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2010-2022 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFE, 2GRFKS; 2GRFE, 2GRFE; GGL15L-AWTGKA, 2GRFKS; GGL15L-AWTGKA, 2GRFKS; GGL25L-AWZGBA, GGL15L-CWTGKA, GGL15L-CWZGKA, GGL25L-AWZGBA, GGL25L-BWZGBA, GGL25L-CWZGBA
View related parts
Lexus RX350 Case Sub-Assy, Rear Differential
Part Number: 41301-48060
$510.83 MSRP: $708.08
You Save: $197.25 (28%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Case, Differential
- Position: Rear
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2010-2022 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFE, 2GRFKS; 2GRFE, 2GRFKS; GGL15L-AWTGKA, GGL15L-CWTGKA, GGL15L-CWZGKA, GGL25L-AWZGBA, GGL25L-BWZGBA, GGL25L-CWZGBA
View related parts
Lexus RX350 Case Sub-Assy, Rear Differential
Part Number: 41301-21060
$547.93 MSRP: $759.51
You Save: $211.58 (28%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Differential
- Position: Rear
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2007-2009 Lexus RX350 | STD | 6 Cyl 3.3L, 6 Cyl 3.5L | 2GRFE, 3MZFE; 2GRFE, 3MZFE; GSU35L-AWAGKA, GSU35L-CWAGKA, MCU38L-AWAGKA, MCU38L-CWAGKA
View related parts
Lexus RX350 Carrier Assy, Differential, Rear
Part Number: 41110-48101
$1090.19 MSRP: $1511.14
You Save: $420.95 (28%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Manufacturer Note: *FGR=41:18=2.277
- Position: Rear
- Replaced by: 41110-48104
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2010-2011 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFE; 2GRFE; GGL15L-AWTGKA, GGL15L-CWTGKA
View related parts
Lexus RX350 Carrier Assy, Differential, Rear
Part Number: 41110-21071
$2046.23 MSRP: $2836.34
You Save: $790.11 (28%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Carrier, Differential Assembly
- Manufacturer Note: *FGR=41:14=2.928
- Position: Rear
- Replaces: 41110-48080, 41110-21070, 41110-48081
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2007-2009 Lexus RX350 | STD | 6 Cyl 3.3L, 6 Cyl 3.5L | 2GRFE, 3MZFE; 2GRFE, 2GRFE; GSU35L-AWAGKA, 2GRFE; GSU35L-CWAGKA, 3MZFE; GSU35L-AWAGKA, 3MZFE; GSU35L-CWAGKA, MCU38L-AWAGKA, MCU38L-CWAGKA
View related parts
Lexus RX350 Case, Front Differential
Part Number: 41301-33120
$627.06 MSRP: $869.18
You Save: $242.12 (28%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Position: Front
- Replaced by: 41301-48120
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2010-2015 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFE; 2GRFE; GGL10L-AWTGKA
View related parts
Lexus RX350 Case Sub-Assembly, Differential
Part Number: 41301-48120
$627.06 MSRP: $869.18
You Save: $242.12 (28%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Case, Front Differential
- Manufacturer Note: *324
- Replaces: 41301-33120
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2010-2015 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFE; 2GRFE; GGL10L-AWTGKA
View related parts
Lexus RX350 Case Sub-Assembly, Differential
Part Number: 41301-48130
$627.06 MSRP: $869.18
You Save: $242.12 (28%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Case, Front Differential
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2014-2015 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFE; 2GRFE; GGL15L-AWTGKA
View related parts
Lexus RX350 Case Sub-Assembly, Differential
Part Number: 41301-07031
$632.34 MSRP: $876.51
You Save: $244.17 (28%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Case, Front Differential
- Manufacturer Note: *325
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2014-2015 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFE; 2GRFE; GGL10L-CWTGKA
View related parts
Lexus RX350 Case, Front Differential
Part Number: 41301-0T011
$632.34 MSRP: $876.51
You Save: $244.17 (28%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Position: Front
- Replaced by: 41301-0T012
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2010-2015 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFE; 2GRFE; GGL15L-CWTGKA
View related parts
Lexus RX350 Case Sub-Assembly, Differential
Part Number: 41301-0T012
$632.34 MSRP: $876.51
You Save: $244.17 (28%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Case, Front Differential
- Replaces: 41301-0T011, 41301-48090
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2010-2015 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFE; 2GRFE; GGL15L-AWTGKA, 2GRFE; GGL15L-CWTGKA
View related parts
Lexus RX350 Case, Front Differential
Part Number: 41301-48090
$632.34 MSRP: $876.51
You Save: $244.17 (28%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Position: Front
- Replaced by: 41301-0T012
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2010-2015 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFE; 2GRFE; GGL15L-AWTGKA
View related parts
Lexus RX350 Case Sub-Assembly, Differential
Part Number: 41301-07030
$695.57 MSRP: $964.14
You Save: $268.57 (28%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Case, Front Differential
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2010-2015 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFE; 2GRFE; GGL10L-CWTGKA
View related parts
Lexus RX350 Carrier Assembly, Differential
Part Number: 41110-48102
$1090.19 MSRP: $1511.14
You Save: $420.95 (28%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Carrier Assy, Differential, Rear
- Manufacturer Note: *FGR=41:18=2.277
- Position: Rear
- Replaced by: 41110-48104
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2010-2012 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFE; 2GRFE; GGL15L-AWTGKA, GGL15L-CWTGKA
View related parts
Lexus RX350 Carrier Assembly, Differential
Part Number: 41110-48103
$1090.19 MSRP: $1511.14
You Save: $420.95 (28%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Other Name: Carrier Assy, Differential, Rear
- Manufacturer Note: *FGR=41:18=2.277
- Position: Rear
- Replaced by: 41110-48104
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2011-2016 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFE, 2GRFKS; 2GRFE, 2GRFKS; GGL15L-AWTGKA, GGL15L-CWTGKA, GGL15L-CWZGKA, GGL25L-AWZGBA, GGL25L-BWZGBA, GGL25L-CWZGBA
View related parts
Lexus RX350 Carrier Assy, Differential, Rear
Part Number: 41110-21070
$2046.23 MSRP: $2836.34
You Save: $790.11 (28%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Manufacturer Note: *FGR=41:14=2.928
- Position: Rear
- Replaced by: 41110-21071
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2007-2008 Lexus RX350 | STD | 6 Cyl 3.3L, 6 Cyl 3.5L | 2GRFE, 3MZFE; 2GRFE, 3MZFE; GSU35L-CWAGKA, MCU38L-CWAGKA
View related parts
Lexus RX350 Carrier Assy, Differential, Rear
Part Number: 41110-48080
$2046.23 MSRP: $2836.34
You Save: $790.11 (28%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Manufacturer Note: *FGR=41:14=2.928
- Position: Rear
- Replaced by: 41110-21071
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2007 Lexus RX350 | STD | 6 Cyl 3.3L, 6 Cyl 3.5L | 2GRFE, 3MZFE; 2GRFE, 3MZFE; GSU35L-AWAGKA, MCU38L-AWAGKA
View related parts
Lexus RX350 Carrier Assy, Differential, Rear
Part Number: 41110-48081
$2046.23 MSRP: $2836.34
You Save: $790.11 (28%)
Ships in 1-3 Business Days
ADD TO CART
Product Specifications
- Manufacturer Note: *FGR=41:14=2.928
- Position: Rear
- Replaced by: 41110-21071
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2007-2009 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFE; 2GRFE; GSU35L-AWAGKA
View related parts
Lexus RX350 Case, Front Differential
Part Number: 41301-07020
Product Specifications
- Manufacturer Note: (L)
- Position: Front
- Replaces: 41301-45020
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2007-2009 Lexus RX350 | STD | 6 Cyl 3.3L, 6 Cyl 3.5L | 2GRFE, 3MZFE; 2GRFE, 2GRFE; GSU30L-CWAGKA, 3MZFE; GSU30L-CWAGKA, MCU33L-CWAGKA
View related parts
Lexus RX350 Case, Front Differential
Part Number: 41301-45020
Product Specifications
- Manufacturer Note: (J)
- Position: Front
- Replaced by: 41301-07020
- Warranty: This genuine part is guaranteed by Lexus's factory warranty.
Fits the following Vehicles:
- 2007 Lexus RX350 | STD | 6 Cyl 3.5L | 2GRFE; 2GRFE; GSU30L-CWAGKA

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1-20 of 25 Results

Lexus RX350 Differential

The Lexus RX350 vehicles come with Differentials that work to transmit power from the engine to the drive wheels so that the car can make smooth turns and even navigate through off-road thee. Characters Interestingly, front-wheel-drive models have the differential on the front axle and rear-wheel-drive cars have it between the rear wheels. There are also central differential systems for moving the 4WD vehicles which is between the front and rear axles. Some cars come with open differentials where the axles get the same amount of power but on the other hand, limited slip differentials distribute power in measures to create better grip. However, both types have the disadvantages, for example, a poor grip on the surface of the ice. Maintenance, and preventive checks for fluid levels and any abnormal sounds from the differential are vital to increasing the component's durability and avoid expensive repairs. Performance upgrades such as LSDs increase the rate at which the vehicle and/or its wheels can accelerate, and the ability to do so on any type of surface.

Should you need to purchase new auto parts for your vehicle, we strongly suggest you consider the genuine Lexus RX350 Differential available on LexusPartsNow.com. Our OEM Lexus RX350 Differential come with the reassurance of the manufacturer's warranty, a hassle-free return policy, and speedy delivery service, all at affordable prices online. Feel free to shop with confidence!

Lexus RX350 Differential Parts Questions & Experts Answers

Carrier Assembly, Differential
41110-48104
Q: How to remove and reinstall the rear differential in a Lexus RX350?
A: Raise the rear of the vehicle, support it on jackstands, block the front wheels, and place the transmission in Neutral with the parking brake off. Drain the differential lubricant. Remove the drive axles from the differential. Mark the relationship of the driveshaft to the pinion flange, then unbolt the driveshaft from the flange and suspend it with wire to avoid stressing the center support bearing. On models with an electromagnetic control coupling, disconnect the electrical connector and secure the harness out of the way. Remove the rear exhaust pipe assembly. On Highlander and 2004 and later RX 330/350 models, remove the rear subframe and differential assembly. Support the differential with a floor jack, remove its mounting bracket and bolts, then lower and remove the differential. Installation is the opposite of removal, ensuring all fasteners are tightened to the appropriate torque values and filling the differential with the correct lubricant.